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Cyclophosphamide treatment has been reported to induce behavioral changes, such as hypomobility, rigidity and involuntary movements, which resemble those observed after dopaminergic denervation. In the present study, we investigated the changes in the sensitivity of adenylate cyclase-coupled dopamine (DA) receptors in the substantia nigra to DA agonists in rats treated with cyclophosphamide. Seven days following treatment with 15 mg/kg of cyclophosphamide, the DA-stimulated adenylate cyclase was significantly decreased in substantia nigra slices and the ED50 value for DA was increased in cyclophosphamide-treated rats. However, the ED50 value for DA and the DA-induced inhibition of forskolin-stimulated adenylate cyclase activity in substantia nigra slices were not increased by pretreatment with cyclophosphamide, which suggests that the decline in the responsiveness of DA receptors is not due to the sensitization of DA receptors by cyclophosphamide. At the ED50 for DA, the sensitivity of DA receptors to a DA receptor agonist (3,4-dihydroxyphenylalanine: L-DOPA) and the intensity of the fluorescence of DA or DA receptor agonists (DA and 3,4-dihydroxyphenyl-N-ethyl-5-methyltetrahydro-2H-1,4-benzodiazepine: D-amphetamine) in the striatum were not changed in cyclophosphamide-treated rats. These results indicate that the sensitivity of DA receptors in the substantia nigra to DA and DA receptor agonists was selectively decreased by cyclophosphamide-induced changes in the postsynaptic portion of DA receptors in the substantia nigra.Q:
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Using NiFi to process an incoming RESTful stream
I have my own REST API that gives a JSON stream of data that represents the current data in a chat room. I have a NiFi processor that I want to put in front of my REST API to provide a better user experience.
I need to use NiFi to process incoming API requests, and with each request, it needs to look up and parse the data in the chat room from the last time I processed the stream, and update the data accordingly. In NiFi, do I need a different flowfile processor for each incoming request, or can I use multiple processors in one flow?
I would prefer to do this in NiFi because I can use and add as many processors as I want, and I don’t have to worry about memory allocation.
NiFi can handle multiple request simultaneously.
You will need the REST flowable for the initial HTTP request to process. This will trigger a flow as it is waiting for the response.
Then you will need the next flowable as the data is parsed. It will parse the JSON from the original flow as that is what the REST flow is waiting